1) Directions by Walking/Tram (RECOMMENDED) - Walk up 2nd Ave to the Tram Entrance between 59th/60th St. Take the tram (buy and use a metro card, which is the main mode of transportation via subway lines in NYC). Walk north up Main St to 455 Main St.
2) Directions by Car/Taxi - Enter 455 Main St. NY NY 10044 into your GPS. If you’re in a yellow cab, you can tell them it’s on Roosevelt Island. Street parking is free, but limited.